Scientific Info on Ayahuasca
Ayahuasca is both a serotonin and dopamine agonist at the same time. The other visionary substances are generally one or the other, ayahuasca is both at the same time. It activates more areas of the brain at once by Affecting GABA through more than one modulating neurotransmitter. The result is more of the brain becomes activated in a better balance than if just one or the other of the modulating neurotransmitters was activated by another single channel GABA inhibiting hallucinogen. In fact, PET scans show neurological activity during ayahuasca experiences raised up to 90% above normal over a wide area of the brain.
Here is the oversimplified short form of what ayahuasca does neurologically, which leads to the explanation of its work as a psychotherapeutic agent and the cause of the “Ayahuasca effect.”
After taking the tea the areas of your brain with the most serotonin and dopamine receptors become uninhibited by GABA and their nuro activity goes up drastically. Think about the word uninhibited for a moment. What do you normally think of when you say that about someone in a psychological sense? It has connotations of being less in control, freer in actions, of not thinking as much before acting. Being uninhibited in this way, and in the neurological sense, is the exact same phenomena.
The frontal cortex of the brain is where most of what you think of as “you” is located. That is, the parts of the personality that makes the executive decisions on what to do in the world, both internal and external, with the thoughts, information and sensation we are presented with. This area of the brain is heavily wired with axons that run directly from the cells that produce serotonin in the brain stem. The prefrontal cortex’s major GABA inhibitor and modulator is serotonin. Ayahuasca therefore dis-inhibits this area of the brain responsible for judgment and decisions. A decision about anything is made by inhibiting the neural patterns of all other possibilities until the one neural pattern remains. If that area of the brain is disinhibited and neural activity remains high, judgments and evaluations become more difficult to make.
In short, you tend to just accept the information and experience you are having without as much filtration and evaluation. It’s a hypnotic state that renders you more open to suggestion and less likely to critically evaluate the experience and information being received by the frontal cortex.
But there is more to the story than just frontal lobe suggestibility. The effects caused by the tea’s actions on dopamine also play an important role in its potential action as a therapeutic agent. Dopamine modulates GABA in much the same way that serotonin does. Two systems in the brain that use dopamine heavily for GABA regulation are the middle brain limbic system and areas of the brain that control fine motor functions that allow us to control smooth motor motions. The limbic system is a central controller and processor of both emotion and memory. In fact, it appears that emotion and the limbic system are key in forming most lasting memories.
One theory of trauma and repression states that when the brain can not assimilate an experience because it is too foreign to its schema, or it’s sense of the way things should be, it represses that experience by sending chemical signals that tell the brain not to use those neural pathways. It stores the experience in pieces all over the brain, but does not complete the integration into memory. Since the instructions not to process, not to be neurologically active, can only be given as GABA signals to keep neurons in the “off” state, this repression of neurological signals must be maintained by modulating neurotransmitters . The presence of elevated levels of dopamine during the ayahuasca experience inhibit GABA in the limbic system, increasing activity there and overriding nurochemical processes that would limit the processing of experiences.
This means that the increase in neural activity in those areas of the brain tends to bring up repressed experiences and start the process of re-integrating them. As these memories and experiences are being once again brought into current processing memory in the mid brain they encounter a brain state profoundly different than the previous state that they were not processed during initially.